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Collagen application for sealing of arterial puncture sites in comparison to pressure dressing: a randomized trial
R Schräder1, S Steinbacher, W Burger
1Abt. f. Kardiologie, ZIM, Center of Internal Medicine, Universitätsklinikum, Theodor Stern-Kai 7, D-6000 Frankfurt am Main 70, Federal Republic of Germany.
Insights
Percutaneously applied collagen significantly reduced compression time and hastened ambulation after femoral artery catheterization compared to traditional pressure dressings. This novel approach also led to fewer bleeding complications and hematomas, improving patient recovery.
Area of Science:
- Cardiology
- Vascular Surgery
- Medical Devices
Background:
- Femoral artery access is common in diagnostic and interventional procedures.
- Hemostasis after femoral artery puncture typically involves manual compression or pressure devices.
- Minimizing complications and recovery time after arterial access is clinically important.
Purpose of the Study:
- To compare the efficacy and safety of percutaneously applied collagen versus conventional pressure dressing for femoral artery sealing.
- To evaluate the impact on compression time, bleeding, hematoma formation, and time to ambulation.
Main Methods:
- A randomized controlled trial involving 100 patients undergoing femoral artery catheterization.
- Patients were assigned to receive either percutaneously applied collagen (n=50) or conventional pressure dressing (n=50).
- Key outcomes measured included compression time, bleeding incidence, hematoma size, and time to ambulation.
Main Results:
- Percutaneous collagen resulted in significantly shorter compression times (4.3 min vs 42.3 min, p < 0.001).
- Bleeding occurred in 0% of patients with collagen versus 12% with pressure dressing (p < 0.05).
- Time to ambulation was markedly reduced with collagen (6.4 hours vs 21.6 hours, p < 0.001), with fewer hematomas.
Conclusions:
- Percutaneously applied collagen is a safe and effective method for femoral artery hemostasis after catheterization.
- Collagen significantly reduces procedure time, shortens recovery, and lowers complication rates compared to conventional dressings.
- This technique offers a valuable alternative for improving patient outcomes and workflow efficiency in vascular access procedures.
Unlabelled:
One-hundred patients undergoing routine diagnostic or interventional catheterization were randomly assigned to receive either percutaneously applied collagen (group A; n = 50) or conventional pressure dressing (group B; n = 50) for sealing of the femoral artery. Clinical variables were comparable in both groups. The heparin dose was 100 IU/kg in 30 patients and 200 IU/kg in 20 patients of either group. The average compression time was 4.3 minutes in group A and 42.3 minutes in group B (p < 0.001). Bleeding was not observed in group A but was observed in 6/50 patients in group B. The time to ambulation was 6.4 hours (range: 4-12 hours) in group A and 21.6 hours (range: 10-48 hours) in group B (p < 0.001). Hematomas with a diameter of > 6 cm developed in 4/50 patients in group A and in 11/50 patients in group B (p < 0.05). Blood transfusion or surgical interventions were not required and there was no loss of ankle pulses in either group.
Conclusion:
Percutaneously applied collagen reduced compression time and duration of bedrest after diagnostic catheterization and PTCA. Despite earlier ambulation, the incidence of bleeding was lower with collagen than with conventional pressure dressing.