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[How relevant is the trough-to peak ratio?]
1Abteilung für Nephrologie/Hypertonie, Inselspital, Bern. paolo.ferrari@insel.ch
Schweizerische Medizinische Wochenschrift
|April 4, 2000
Summary
The trough-to-peak ratio for antihypertensive drugs is a problematic surrogate endpoint. It does not predict clinical efficacy, making 24-hour blood pressure monitoring a more reliable measure.
Area of Science:
- Cardiology
- Pharmacology
Context:
- Morning hypertension is linked to cardiovascular events.
- Nocturnal blood pressure dips correlate with cardiac and vascular health.
Purpose:
- To review the trough-to-peak ratio's utility in assessing antihypertensive drug action duration.
- To highlight limitations of the trough-to-peak ratio as a surrogate endpoint.
Summary:
- The trough-to-peak ratio is an arithmetic index used for antihypertensive drug evaluation.
- This ratio may influence drug choice but doesn't predict clinical efficacy.
- Lack of standardized methods and optimal values makes the trough-to-peak ratio clinically problematic.
Impact:
- Recommends 24-hour blood pressure monitoring over the trough-to-peak ratio for assessing antihypertensive drug efficacy.
- Highlights the need for reproducible parameters in clinical practice.
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