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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

Effect of administering short-course, standardized regimens in individuals infected with drug-resistant Mycobacterium

J J Furin1, M C Becerra, S S Shin

  • 1Department of Social Medicine, Harvard Medical School, Boston, MA 02115, USA. JENFURIN@AOL.COM

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
|April 4, 2000
PubMed

Insights

Standard tuberculosis treatment before susceptibility testing can worsen drug resistance. Three siblings developed multidrug-resistant tuberculosis due to ineffective chemotherapy regimens.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Genetics

Background:

  • Multidrug-resistant tuberculosis (MDR-TB) poses a significant global health challenge.
  • Standard treatment regimens for tuberculosis (TB) aim to eradicate Mycobacterium tuberculosis.
  • Drug susceptibility testing (DST) is crucial for guiding effective TB therapy.

Observation:

  • Three siblings with MDR-TB showed increased drug resistance during treatment.
  • Resistance developed to drugs used in standard and retreatment regimens.
  • This occurred before Mycobacterium tuberculosis isolate susceptibility patterns were determined.

Findings:

  • Inadequate or ineffective chemotherapy can inadvertently promote antituberculous-drug resistance.
  • The development of acquired resistance was linked to the specific drugs administered.
  • Pre-treatment DST is critical to prevent treatment failure and resistance amplification.

Implications:

  • Clinical guidelines should emphasize timely DST before initiating or altering TB treatment.
  • Failure to perform DST can lead to treatment failure and the emergence of more resistant strains.
  • This case series highlights the critical need for personalized medicine in managing complex TB cases.

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