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Unusual phenolic glycosides from Cotoneaster orbicularis.
A M El-Mousallamy1, S A Hussein, I Merfort
1National Research Centre, El-Dokki, Cairo, Egypt.
Phytochemistry
|April 4, 2000
Summary
The Cotoneaster orbicularis plant yielded two novel compounds: a di-C-glycosylflavone and a phenolic glucoside named orbicularin. These findings expand the known phytochemical profile of this plant species.
Area of Science:
- Phytochemistry
- Natural Product Chemistry
- Plant Sciences
Background:
- Cotoneaster orbicularis is a plant species with a rich but not fully characterized phytochemical profile.
- Understanding the chemical constituents of medicinal plants is crucial for drug discovery and ethnobotanical research.
Purpose of the Study:
- To isolate and identify novel compounds from the whole plant of Cotoneaster orbicularis.
- To characterize the chemical structures of these newly discovered natural products.
Main Methods:
- Extraction and isolation of phenolic compounds from Cotoneaster orbicularis.
- Structure elucidation using routine analytical methods, including 1H and 13C Nuclear Magnetic Resonance (NMR) spectroscopy.
Main Results:
- Identification of a novel di-C-glycosylflavone, 6,8-di-C-beta-Cellobiosylapigenin (vicenin II derivative).
- Discovery of a new natural phenolic glucoside, gentisic acid 2-O-beta-glucopyranoside (orbicularin).
- Characterization of additional known phenolic compounds including various acids, flavonoids, and their glycosides.
Conclusions:
- The phytochemical investigation of Cotoneaster orbicularis has led to the discovery of two previously unknown natural compounds.
- The identified compounds, including orbicularin and a vicenin II derivative, contribute significantly to the known chemical diversity of the Cotoneaster genus.