Microvascular endothelium dysfunction during growth of transplanted lymphosarcoma and glioma in rats

The changes of endothelium functional parameters (adhesivity, permeability, thrombogenity and thromboresistance) in mesenteric microvasculature in rats with two transplanted tumors: fast-growing Pliss' lymphosarcoma (PLS) and slow-growing glioma-35 (G-35) were studied, using a complex method, based upon a computer-assisted microscopic video image processing. The endothelial dysfunction in mesenteric microvessels is characterized by the increase of leukocyte adhesion to the endothelial cells, microvessels permeability and their thromboresistance properties decrease in tumor-bearing rats. The observed changes are shown to be the nonspecific manifestation of the tumor process development. They are determined by the duration of the process development and are not dependent on the tumor node size.