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Mixed follicular and parafollicular thyroid carcinoma
P Vitri1, A Galimberti, L De Pasquale
1II Dept. of General Surgery L. Sacco Hospital, University of Milan, Italy. kozman.vitripat@iol.it
Journal of Experimental & Clinical Cancer Research : CR
|April 4, 2000
Abstract:
A rare case of mixed follicular-parafollicular thyroid carcinoma which occurred in a 50-year-old man, is reported. The ultrastructural aspects of the tumor showed: a biphasic growth pattern with microfolliculi and solid areas; the coexpression of thyroglobulin and calcitonin antigens in the same follicle-like structures; the presence of neuroendocrine granules, microvilli and intracytoplasmic canaliculi bordered by microvilli. These characteristics lead us to a diagnosis of mixed follicular-parafollicular thyroid carcinoma.