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Palladium-catalyzed synthesis of cephalotaxine analogues
L F Tietze1, H Schirok, M Wöhrmann
1Institut für Organische Chemie der Universität, Göttingen, Germany. ltietze@gwdg.de
Chemistry (Weinheim an Der Bergstrasse, Germany)
|April 5, 2000
Abstract:
The synthesis of cephalotaxine ring analogues 10 was achieved by two successive intramolecular palladium-catalyzed reactions of 12 via 11, namely an allylic amination and a Heck reaction. The substrates 12 were obtained by alkylation of primary amines 13 with tosylates 14.