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Related Experiment Videos

Macronutrient diet selection in thirteen mouse strains.

B K Smith1, P K Andrews, D B West

  • 1Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808-4124, USA.

American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
|April 6, 2000
PubMed
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Mouse strains show significant differences in macronutrient diet selection, particularly fat intake. This variation highlights genetic influences on dietary preferences and obesity sensitivity.

Area of Science:

  • Genetics
  • Nutritional Science
  • Animal Models

Background:

  • Dietary macronutrient selection is a complex trait influenced by genetics.
  • Understanding genetic variation in diet selection is crucial for studying obesity and metabolic diseases.

Purpose of the Study:

  • To investigate macronutrient diet selection across 13 inbred mouse strains.
  • To identify genetic factors influencing fat consumption and its relationship with obesity.

Main Methods:

  • Utilized a self-selection protocol with separate carbohydrate, fat, and protein diets.
  • Monitored diet selection over 26-30 days in 13 mouse strains.
  • Correlated epididymal fat depot weight with fat consumption.

Main Results:

Related Experiment Videos

  • Significant strain-dependent differences in macronutrient selection were observed, with fat intake ranging from 26% to 83% of total energy.
  • AKR/J, NZB/B1NJ, and C57BL/6J mice selected the highest proportion of fat, while CAST/Ei and BALB/cByJ selected the lowest.
  • Positive correlations between fat intake and fat depot weight in obesity-sensitive strains (AKR/J, C57BL/6J), and inverse correlations in lean strains (SWR/J, CAST/Ei).

Conclusions:

  • Inbred mouse strains exhibit distinct patterns of macronutrient diet selection, indicating a strong genetic component.
  • Dietary fat selection varies considerably, offering a valuable tool for genetic dissection of this trait.
  • Hypothesized differential sensitivity to negative feedback signals regulating fat accumulation across strains.