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Rat small mesenteric artery function after hindlimb suspension.

R C Looft-Wilson1, C V Gisolfi

  • 1Department of Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA.

Journal of Applied Physiology (Bethesda, Md. : 1985)
|April 6, 2000
PubMed
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Simulated microgravity in rats attenuated myogenic tone in mesenteric arteries. This vascular dysfunction may contribute to orthostatic intolerance, impacting astronaut health.

Area of Science:

  • Cardiovascular Physiology
  • Space Medicine
  • Vascular Biology

Background:

  • Simulated microgravity via hindlimb suspension (HS) is a model for studying spaceflight effects on the cardiovascular system.
  • Vascular dysfunction, including impaired myogenic tone, is a potential consequence of microgravity exposure.
  • Understanding these changes is crucial for mitigating health risks in astronauts.

Purpose of the Study:

  • To investigate the impact of 28-day hindlimb suspension (HS) on vascular function in rat mesenteric resistance arteries.
  • To determine if simulated microgravity affects responses to vasoconstrictors, pressure, and shear stress.
  • To assess changes in myogenic tone, a critical determinant of vascular resistance.

Main Methods:

  • Isolated, pressurized rat mesenteric resistance artery segments were used.
Keywords:
NASA Discipline CardiopulmonaryNASA Program Biomedical Research and CountermeasuresNon-NASA Center

Related Experiment Videos

  • Arteries were subjected to 28 days of hindlimb suspension (HS) or served as controls (C).
  • Vascular responses to vasoconstrictors (norepinephrine, phenylephrine, serotonin, KCl), pressure, and shear stress were measured.

    • Main Results:

    • No significant differences were observed between HS and C groups in vasoconstrictor sensitivity, maximal responses, vessel dimensions, or distensibility.
    • Vasodilatory responses to shear stress were also comparable between groups.
    • Myogenic tone was significantly attenuated in HS arteries compared to controls, particularly in larger and smaller mesenteric vessels at specific pressures.

    Conclusions:

    • Simulated microgravity (HS) does not alter basal vascular dimensions or responses to vasoconstrictors and shear stress.
    • A key finding is the significant attenuation of myogenic tone in mesenteric resistance arteries after HS.
    • This reduction in myogenic tone may contribute to orthostatic intolerance, a common issue faced by astronauts upon returning to Earth.