Oral pulsed high-dose dexamethasone for myositis
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Published on: May 24, 2016
M F van der Meulen1, J E Hoogendijk, J H Wokke
1Department of Neurology, University Medical Centre, Utrecht, The Netherlands. M.F.G.vdMeulen@neuro.azu.nl
Abstract:
To study the short-term effect of oral pulsed high-dose dexamethasone for myositis we treated eight newly diagnosed patients with three 28-day cycles of oral dexamethasone. Primary outcome measures were muscle strength, pain, and serum creatine kinase activity. Six patients responded. Side effects were mild. At follow-up five responders were still in remission, without medication. Pulsed high-dose dexamethasone seems beneficial in myositis. A larger, prednisone-controlled trial is justified to analyze long-term efficacy.
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