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[Low expression of nm23-H1 mRNA and its protein in breast cancer]
1Department of General Surgery, Dalian Central Hospital, Dalian, Liaoning, 116033 P.R.China.
Objective:
To explore the expression of nm23-H1 mRNA and its protein in breast cancer and its correlation to the biologic behavior.
Methods:
RT-PCR and immunohistochemical method were employed to detect the expression of nm23-H1 mRNA and its protein in 58 breast cancer tissues.
Results:
Low level expression of nm23-H1 mRNA and protein was shown in 44.8% and 48.2% of examined cases respectively. The low expression of nm23-H1 mRNA was correlated, but not always parallel to the protein expression. The low level expression of nm23-H1 mRNA or the protein was significantly associated with lymphatic metastasis of the cancer.
Conclusion:
Examination of nm23-H1 expression may be of significance in evaluating metastatic potentiality and prognosis of breast cancer.