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[Genetic polymorphism of 5 STR loci on chromosome 14 in Chinese Han]
1Department of Medical Genetics, Shandong Medical University, Jinan, Shandong, 250012 P.R.China. chenhongguo@mailcity.com.
Objective:
To understand the distribution of genes and genotypes of 5 STR loci on chromosome 14 in Chinese Han.
Methods:
PCR and polyacrylamide gel electrophoresis were used to analyze the polymorphism of 5 STR loci (D14S742, D14S306, D14S606, D14S617, D14S611) on chromosome 14 in Chinese Han.
Results:
5 alleles and 13 genotypes, 5 alleles and 13 genotypes, 6 alleles and 13 genotypes, 9 alleles and 21 genotypes, and 6 alleles and 13 genotypes were observed at D14S742, D14S306, D14S606, D14S617 and D14S611, respectively. The frequencies of the most common allele at these five loci were 0.31, 0.31, 0.47, 0.35 and 0.29 respectively.
Conclusion:
These five loci are highly polymorphic in Chinese Han and their allele distribution is in good agreement with Hardy-Weinberg equilibrium.