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Updated: Oct 17, 2026

An Obstructive Chronic Pancreatitis Model Established Through Electrocoagulation
Published on: October 31, 2025
[Pancreatic anatomopathologic changes in chronic chagasic women. Preliminary data]
V M dos Santos1, V de P Teixeira, D F da Cunha
1Departamento de Clínica Médica da Faculdade de Medicina do Triângulo Mineiro, FTTM, Uberaba, MG.
Abstract:
The aim of this study was to compare the frequency of pancreas morphologic and morphometric changes in chagasic women (n = 6) aged > or = 40 years, with non-chagasic controls (n = 4), paired concerning to age (59.8 +/- 11.5 versus 59.0 +/- 6.3 years), white color (33.3% versus 50.0%) and body mass index (22.3 +/- 7.0 versus 18.8 +/- 2.1 kg/m2). There were no pancreatic morphometric differences between necropsied chagasic and control groups. However, there was a smaller intrapancreatic neuronal population and a higher frequency of leukocyte perineural infiltrate in the pancreas of chagasic women. This possible intrapancreatic denervation could be associated with changes in carbohydrate metabolism, including hyperglycemia and diabetes mellitus, in some chronic chagasic women.
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Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
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