Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of human circadian rhythms.

G Copinschi1, K Spiegel, R Leproult

  • 1Centre for the Study of Biological Rhythms, Université Libre de Bruxelles, Belgium.

Novartis Foundation Symposium
|April 7, 2000
PubMed
Summary

Hormonal secretion patterns reveal the human circadian system

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Business-centric data solutions for safeguarding animal agriculture in the United States of America.

Revue scientifique et technique (International Office of Epizootics)·2023
Same author

Illegal and Therapeutic Drug Concentrations in Hair Segments - A Timetable of Drug Exposure?

Forensic science review·2015
Same author

Circadian rhythm of circulating levels of the endocannabinoid 2-arachidonoylglycerol.

The Journal of clinical endocrinology and metabolism·2014
Same author

Adverse effects of two nights of sleep restriction on the hypothalamic-pituitary-adrenal axis in healthy men.

The Journal of clinical endocrinology and metabolism·2014
Same author

[Current developments in measuring quality of life with instruments of the European organisation for research and treatment of cancer (EORTC)].

Laryngo- rhino- otologie·2011
Same author

Sleep disturbances and insulin resistance.

Diabetic medicine : a journal of the British Diabetic Association·2011

Area of Science:

  • Chronobiology
  • Endocrinology
  • Physiology

Background:

  • The 24-hour profiles of hormonal secretions serve as a model for studying the human circadian system.
  • Diurnal hormonal variations result from the interplay of the internal circadian clock, sleep-wake homeostasis, and environmental factors like light, activity, and meals.
  • Temporal organization is disrupted in conditions such as aging, sleep loss, shift work, jet lag, mood disorders, and endocrine diseases.

Purpose of the Study:

  • To explore the regulation of the circadian pacemaker and its impact on hormonal secretion patterns.
  • To investigate how photic and non-photic stimuli influence the circadian clock and hormonal rhythms.
  • To examine the potential of timed stimuli for treating circadian rhythm disorders.

Main Methods:

  • Analysis of 24-hour hormonal secretion profiles.
  • Investigation of interactions between the circadian clock, sleep-wake homeostasis, and environmental cues.
  • Assessment of phase-shifting effects of various stimuli on the circadian clock.

Main Results:

  • Appropriately timed stimuli can induce phase-advances or phase-delays of the circadian clock.
  • Phase-shifting effects were demonstrated for light, dark pulses, exercise, melatonin, melatonin agonists, and benzodiazepines.
  • These findings highlight the plasticity of the human circadian system.

Conclusions:

  • The study of hormonal profiles provides insights into circadian rhythm regulation.
  • Timed administration of specific stimuli can effectively modulate the circadian clock.
  • These findings offer new therapeutic strategies for circadian rhythm dysregulation disorders.

Related Experiment Videos