Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Pulsatile insulin secretion.

¹Department of Medicine, University of Edinburgh, Western General Hospital, UK.

Novartis Foundation Symposium

|April 7, 2000

Summary

This summary is machine-generated.

Type 2 diabetes is linked to abnormal insulin secretion patterns. The main issue is reduced insulin pulse mass, not pulse frequency, which can be improved by resting beta cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Fostering innovation and sustainable thinking in surgery: an evaluation of a surgical hackathon.

Annals of the Royal College of Surgeons of England·2024

Same author

SU-E-I-60: Validation of An Optically Stimulated Luminescent (OSL) Dosimeter for Use in Output Exposure Control Verification of Mammography Imaging Systems.

Medical physics·2017

Same author

Necrotising fasciitis caused by metastatic endometrial cancer: a rare cause of a life-threatening condition.

Annals of the Royal College of Surgeons of England·2016

Same author

Optimising faecal occult blood screening:retrospective analysis of NHS Bowel Cancer Screening data to improve the screening algorithm.

British journal of cancer·2014

Same author

The psychological impact of facial changes in scleroderma.

Psychology, health & medicine·2011

Same author

Accumulation and metabolism of drugs and CYP probe substrates in zebrafish larvae.

Xenobiotica; the fate of foreign compounds in biological systems·2010

Same journal

Genetic and therapeutic control of diabetogenic CD8+ T cells.

Novartis Foundation symposium·2009

Same journal

Translating mucosal antigen based prevention of autoimmune diabetes to human.

Novartis Foundation symposium·2009

Same journal

Re-establishing immune tolerance in type 1 diabetes via regulatory T cells.

Novartis Foundation symposium·2009

Same journal

Immune markers of disease and therapeutic intervention in type 1 diabetes.

Novartis Foundation symposium·2009

Same journal

Towards a curative therapy in type 1 diabetes: remission of autoimmunity, maintenance and augmentation of beta cell mass.

Novartis Foundation symposium·2009

Same journal

CD8 and cytotoxic T cells in type 1 diabetes.

Novartis Foundation symposium·2009

See all related articles

Area of Science:

Endocrinology
Metabolic Research

Background:

Insulin is secreted in pulsatile bursts approximately every 6 minutes.
Insulin secretion rate is regulated by modulating the mass of these bursts.
Hepatic insulin clearance is related to insulin delivery patterns.

Purpose of the Study:

To investigate abnormalities in pulsatile insulin secretion in type 2 diabetes.
To identify the primary defect in insulin secretion in type 2 diabetes.
To explore potential therapeutic strategies for improving insulin secretion.

Main Methods:

Utilized sensitive insulin assays (ELISA).
Employed validated methods for pulse detection.
Examined pulsatile insulin patterns in patients with type 2 diabetes.

Related Experiment Videos

Main Results:

Identified a deficient insulin pulse mass as the principal defect in type 2 diabetes.
Observed no significant changes in insulin pulse frequency.
Demonstrated that beta cell rest can overcome the deficient pulse mass.

Conclusions:

The primary defect in type 2 diabetes is reduced insulin pulse mass.
Resting beta cells offers a potential therapeutic approach.
Understanding pulsatile insulin secretion is crucial for managing type 2 diabetes.