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Updated: Aug 10, 2026

Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
Published on: August 25, 2023
Malignant spinal neurofibrosarcoma
R Kett-White1, J L Martin, E W Jones
1Department of Neurosurgery, Morriston Hospital, Swansea, Wales, United Kingdom.
Study Design:
A report of a case of metastatic spinal neurofibrosarcoma.
Objective:
To document metastatic neurofibrosarcoma as a cause of spinal cord compression and to review the literature.
Summary Of Background Data:
Three previously reported cases of metastatic neurofibrosarcoma of the spine were reviewed.
Methods:
The patient's clinical record and radiologic investigations as well as the result of a search of the English literature are reported. Magnetic resonance images, computed tomographic scans, and histology photomicrographs are displayed.
Results:
Paraparesis developed in this patient, due to a posterior extradural thoracic spinal cord compression by a neurofibrosarcoma believed to be metastatic from a neurofibrosarcoma of the femoral nerve.
Conclusions:
Malignant spinal metastasis remains a rare complication of neurofibromatosis, with a very poor prognosis.

