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Difference in the in-hospital mortality of unstable angina pectoris between men and women

L C Passos1, A A Lopes, U Costa

  • 1Fundação Bahiana de Cardiologia, Hospital Universitário Prof. Edgar Santos, Salvador, Brazil.

Arquivos Brasileiros De Cardiologia
|February 7, 2001
PubMed

Insights

In-hospital mortality from unstable angina pectoris (UA) was three times higher for women than men. This disparity persisted across various patient factors, including age and coronary heart disease risk.

Area of Science:

  • Cardiology
  • Public Health

Background:

  • Unstable angina pectoris (UA) is a critical manifestation of coronary heart disease.
  • Understanding sex-based differences in UA outcomes is crucial for targeted interventions.

Purpose of the Study:

  • To investigate in-hospital mortality (HM) disparities between men and women with UA.
  • To analyze the influence of age, ST segment depression, prior myocardial infarction (AMI), and cardiovascular risk factors on these sex-based differences.

Main Methods:

  • A cohort of 261 UA patients was analyzed from October 1996 to March 1998.
  • Logistic regression models were employed to adjust for covariates like hypertension, diabetes, dyslipidemia, sedentary lifestyle, smoking, and family history.
  • In-hospital mortality (HM) was the primary outcome measure.

Main Results:

  • Women experienced approximately three times higher in-hospital mortality (9.3%) compared to men (3.0%) with UA.
  • The elevated mortality risk in women (relative risk = 3.07) remained significant after adjusting for multiple cardiovascular risk factors.
  • Logistic regression analysis indicated that age, ST segment depression, prior AMI, and cardiovascular risk factors did not significantly alter the association between sex and mortality.

Conclusions:

  • In-hospital mortality for unstable angina pectoris (UA) is significantly higher in women than in men.
  • This sex-based disparity in UA mortality is not substantially influenced by age, electrocardiographic findings, or common cardiovascular risk factors.
Abstract

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