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Remission of relapsing childhood nephrotic syndrome with mycophenolate mofetil
M Chandra1, M Susin, C Abitbol
1Department of Pediatrics, North Shore University Hospital, New York University School of Medicine, Manhasset 11030, USA.
Abstract:
We report a 21-year-old male with childhood-onset familial nephrotic syndrome and frequent relapses who manifested toxicity or treatment resistance to corticosteroids, cyclophosphamide, cyclosporin-A, and tacrolimus. Monotherapy with mycophenolate mofetil (MMF) resulted in maintenance of clinical remission for 14 months without noticeable toxicity, while allowing resolution of steroid-induced side effects. Our observation suggests that MMF may be useful in maintaining remission in nephrotic patients who manifest toxicity to standard immunosuppressive agents.
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