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Nitrofurantoin-induced lung disease: two cases demonstrating resolution of apparently irreversible CT abnormalities
R E Sheehan1, A U Wells, D G Milne
1Department of Radiology, Royal Brompton Hospital, London, England.
Abstract:
A reticular pattern on high resolution CT (HRCT) invariably represents significant lung pathology and is the dominant feature of irreversible fibrosis. We present two cases of nitrofurantoin-induced pulmonary toxicity in which the initial HRCT showed a widespread reticular pattern and associated distortion of the lung parenchyma, thought to represent established fibrosis. Follow-up HRCT scans after withdrawal of the drug showed resolution of this supposedly irreversible pattern.
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