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Transplacental passage of iohexol
A J Moon1, R W Katzberg, M P Sherman
1Division of Neonatology, Department of Pediatrics and the Department of Diagnostic Radiology, University of California Davis Medical Center, Sacramento, CA 95616, USA.
The Journal of Pediatrics
|February 7, 2001
Summary
Iohexol, a radiographic contrast agent, appeared in fetal intestines after maternal angiography. This facilitated the identification of an omphalomesenteric duct cyst in one twin neonate.
Area of Science:
- Medical Imaging
- Fetal Medicine
- Radiology
Background:
- Nonionic radiographic contrast agents are utilized in maternal angiography.
- These agents are known to cross the human placenta and reach fetal circulation.
Observation:
- Iodinated, low molecular weight radiographic contrast agent (iohexol) was administered to a pregnant mother during angiography.
- The contrast agent was subsequently observed within the intestines of twin neonates.
Findings:
- The presence of iohexol in the fetal gastrointestinal tract was confirmed.
- This facilitated the prenatal diagnosis of an omphalomesenteric duct cyst in one of the twins.
Implications:
- Demonstrates transplacental passage and fetal gastrointestinal excretion of iohexol.
- Highlights the utility of contrast-enhanced fetal imaging for diagnosing congenital anomalies.
- Suggests potential for further research into fetal exposure to radiographic agents.