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Round-Window Microcatheter-Administered Microdose Gentamicin: Results from Treatment of Tinnitus Associated with

DeCicco1, Hoffer, Kopke

  • 1Department of Defense Spatial Orientation Center, Department of Otolaryngology, Naval Medical Center, San Diego, CA.

The International Tinnitus Journal
|February 7, 2001
PubMed

Insights

Microdose gentamicin delivered via the Round Window Microcatheter effectively treated Menière

Area of Science:

  • Otolaryngology
  • Neurosurgery
  • Pharmacology

Background:

  • Menière's disease is a chronic inner ear disorder.
  • Symptoms include vertigo, tinnitus, and aural pressure.
  • Current treatments have limitations.

Purpose of the Study:

  • To evaluate the efficacy and safety of microdose gentamicin delivered via the Round Window Microcatheter for Menière's disease.

Main Methods:

  • 18 patients with Menière's disease were treated.
  • Microdose gentamicin was delivered directly to the round window.
  • Follow-up ranged from 6 to 18 months.

Main Results:

  • Vertigo was eliminated in 100% of patients.
  • Tinnitus improved in 83% of patients.
  • Aural pressure was relieved in 94% of patients.

Conclusions:

  • Round Window Microcatheter-delivered gentamicin is a safe and effective treatment.
  • This method significantly reduces Menière's disease symptoms.
  • Further research is warranted.

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