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Updated: Aug 13, 2026

Isolation and Cultivation of Neural Progenitors Followed by Chromatin-Immunoprecipitation of Histone 3 Lysine 79 Dimethylation Mark
Published on: January 26, 2018
Locus control regions and epigenetic chromatin modifiers
1Department of Medicine, Gene Control Mechanisms and Disease, Imperial College School of Medicine, Medical Research Council, Clinical Sciences Centre, Hammersmith Hospital, London, W12 ONN. r-festen@nimr.mrc.ac.uk
Abstract:
Locus control regions are defined as gene regulatory sequences that enable chromosomal position-independent gene expression in transgenic mice. Recent studies have shown the ability of such regions to overcome the highly repressive effect of heterochromatin and have identified both trans-acting and cis-acting factors that participate in gene silencing and activation mechanisms.
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