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The uniqueness of the imprinting mechanism
F Sleutels1, D P Barlow, R Lyle
1Department of Molecular Genetics, The Netherlands Cancer Institute, Amsterdam, 1066CX, The Netherlands.
Current Opinion in Genetics & Development
|April 8, 2000
Abstract:
An epigenetic imprinting mechanism that is based on a gamete-specific methylation imprint restricts expression of a subset of mammalian genes to one parental chromosome. Recent results suggest that imprints may act only indirectly to induce monoallelic expression of coding genes. Instead, atypical non-coding RNAs appear to be a primary target of the imprints, and their parental-specific repression correlates with parental-specific expression of linked coding genes.