Nucleic acids: theory and computer simulation, Y2K
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Updated: Oct 17, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
Published on: December 29, 2021
1Chemistry Department, Molecular Biophysics Program, Wesleyan University, Middletown, CT 06459, USA. dbeveridge@wesleyan.edu
Abstract:
Molecular dynamics simulations on DNA and RNA that include solvent are now being performed under realistic environmental conditions of water activity and salt. Improvements to force-fields and treatments of long-range interactions have significantly increased the reliability of simulations. New studies of sequence effects, axis bending, solvation and conformational transitions have appeared.
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