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Primary penile lymphoma: diagnostic difficulties and management options
D W Lin1, D R Thorning, J N Krieger
1Department of Urology, University of Washington Medical Center, Seattle, Washington, USA.
Urology
|February 7, 2001
Summary
A rare case of CD30-positive anaplastic large cell lymphoma presenting as a penile ulcer in a 76-year-old man was successfully treated with CO2 laser excision and penile reconstruction, showing no recurrence after 18 months.
Area of Science:
- Oncology
- Dermatology
- Urology
Background:
- Penile ulcers can have various etiologies, necessitating thorough differential diagnosis.
- Anaplastic large cell lymphoma (ALCL) is a rare non-Hodgkin lymphoma that can manifest in extranodal sites.
- CD30 is a key marker in the diagnosis of ALCL.
Observation:
- A 76-year-old male presented with a painless penile ulcer.
- Initial extensive workup for common causes of penile ulcers was negative.
- CO2 laser excision and penile reconstruction were performed for the lesion.
Findings:
- Histologic examination confirmed anaplastic, large cell lymphoma with CD30-positive cells.
- Staging computed tomography scans of the thorax, abdomen, and pelvis were negative, indicating localized disease.
- The patient received no adjuvant therapy and remained disease-free for 18 months post-surgery.
Implications:
- This case highlights the importance of considering rare hematologic malignancies in the differential diagnosis of penile lesions.
- Surgical excision may be a viable primary treatment for localized primary penile ALCL.
- Further research into optimal management strategies for this rare presentation is warranted.
