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Updated: Aug 4, 2026

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
Published on: April 29, 2010
PriA-directed replication fork restart in Escherichia coli
1Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. k-marians@ski.mskcc.org
Abstract:
The encounter of a replication fork with either a damaged DNA template, a nick in the template strand or a 'frozen' protein-DNA complex can stall the replisome and cause it to fall apart. Such an event generates a requirement for replication fork restart if the cell is going to survive. Recent evidence shows that replication fork restart is effected by the action of the recombination proteins generating a substrate for PriA-directed replication fork assembly.
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