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Links between replication, recombination and genome instability in eukaryotes
1Ludwig Institute for Cancer Research, Cancer Center and Dept of Medicine, University of California-San Diego School of Medicine, La Jolla, CA 92093, USA.
Trends in Biochemical Sciences
|April 8, 2000
Abstract:
Double-strand breaks in DNA can be repaired by homologous recombination including break-induced replication. In this reaction, the end of a broken DNA invades an intact chromosome and primes DNA replication resulting in the synthesis of an intact chromosome. Break-induced replication has also been suggested to cause different types of genome rearrangements.