Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Centromerization.

K H Choo1

  • 1The Murdoch Institute, Royal Children's Hospital, Flemington Road, Parkville 3052, Melbourne, Australia. choo@cryptic.rch.unimelb.edu.au

Trends in Cell Biology
|April 8, 2000
PubMed
Summary
This summary is machine-generated.

Centromere formation begins with epigenetic marking of DNA, independent of specific sequences. This process establishes unique chromatin for centromere development and kinetochore assembly.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Susceptibility of metallothionein-null mice to paraquat.

Environmental toxicology and pharmacology·2011
Same author

Methylation of novel markers of fragile X alleles is inversely correlated with FMRP expression and FMR1 activation ratio.

Human molecular genetics·2010
Same author

Removal of manganese from water using combined chelation/membrane separation systems.

Water science and technology : a journal of the International Association on Water Pollution Research·2005
Same author

A pilot-scale photocatalyst-membrane hybrid reactor: performance and characterization.

Water science and technology : a journal of the International Association on Water Pollution Research·2005
Same author

Domain organization at the centromere and neocentromere.

Developmental cell·2001
Same author

Mosaic inv dup(8p) marker chromosome with stable neocentromere suggests neocentromerization is a post-zygotic event.

American journal of medical genetics·2001

Area of Science:

  • Epigenetics
  • Molecular Biology
  • Chromatin Biology

Background:

  • Centromere formation is crucial for accurate chromosome segregation during cell division.
  • This process involves specialized chromatin and protein assembly, including kinetochore proteins.
  • Early centromerization steps appear independent of DNA sequence, suggesting epigenetic regulation.

Purpose of the Study:

  • To discuss epigenetic mechanisms influencing centromere chromatin organization.
  • To evaluate the roles of these mechanisms as primary triggers for centromerization.
  • To review recent data on epigenetic control of centromere formation.

Main Methods:

  • Literature review and data synthesis.
  • Analysis of proposed epigenetic mechanisms.

Related Experiment Videos

  • Discussion of experimental evidence regarding centromerization triggers.

    • Main Results:

    • Epigenetic influences are critical in the initial DNA-sequence-independent marking of centromere regions.
    • Several epigenetic mechanisms can alter centromere chromatin organization.
    • The relative roles of these mechanisms as primary centromerization triggers are under investigation.

    Conclusions:

    • Epigenetic factors play a significant role in initiating centromere formation.
    • Understanding these epigenetic triggers is key to deciphering centromere specification.
    • Further research is needed to fully elucidate the primary epigenetic mechanisms driving centromerization.