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Synthesis of 7-substituted tetracycline derivatives
1Department of Science and Allied Health, Mount Ida College, Newton, Massachusetts 02459, USA. dkoza@mountida.edu
Organic Letters
|February 7, 2001
Abstract:
[formula: see text] The synthesis of 7-substituted tetracycline derivatives has been accomplished in high yield from 7-halotetracyclines by modified Suzuki and Stille coupling protocols. These novel derivatives may serve as a new class of tetracycline antibiotics effective against multi-antibiotic-resistant bacteria.