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Determination of amylose/particulate relationship in hydroxyethylstarch
D Stephens1, D Bares, D Robinson
1Abbott Laboratories, Hospital Products Division, Abbott Park, IL 60064-3500, USA.
Abstract:
Visual particulate was observed to form in parenteral hydroxyethylstarch over 24 months during stability studies. The particulate was identified as being amylose using FT-IR microscopy. Amylose values were measured in the bulk drug using the starch-iodine reaction. The amylose numbers measured in the bulk drug were found to correlate well with the measured particulate values in the parenteral formulation.
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