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Related Experiment Videos

[Physiology of cough].

J Moinard1, G Manier

  • 1Centre de Pneumologie, Bordeaux. moinard@quaternet.fr

Revue Des Maladies Respiratoires
|April 11, 2000
PubMed
Summary

Coughing involves airway receptors sending signals to the brain. Understanding this complex reflex, including rapidly adapting receptors (RARs) and C fibers, aids in managing persistent cough.

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Area of Science:

  • Neuroscience
  • Respiratory Medicine
  • Physiology

Context:

  • Cough is a vital protective reflex involving the larynx and upper airways.
  • The central nervous system's role in the cough reflex loop is not fully understood.
  • Afferent pathways involve specialized receptors within airway epithelial cells.

Purpose:

  • To elucidate the poorly understood central organization of the cough reflex.
  • To detail the roles of rapidly adapting receptors (RARs) and C fibers in cough.
  • To explore the interaction between these receptors and neurogenic inflammation.

Summary:

  • Cough is triggered by activated receptors in the larynx and upper airways, transmitting signals to the central nervous system.
  • Rapidly adapting receptors (RARs), linked to vagus nerve fibers, and C fibers, which release neuropeptides causing neurogenic inflammation, are key components.
  • The cough reflex threshold is determined by the complex interplay between RARs and C fibers, involving both peripheral and central mechanisms.

Impact:

  • Enhanced understanding of cough mechanisms can lead to improved patient management strategies.
  • Identifying the triggers and control of cough can optimize treatments for chronic cough conditions.
  • This research provides a foundation for developing targeted therapies for cough-related disorders.

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