Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Molecular diagnostic tests and chromosome analyses].

T Honda1, E Hidaka, I Ueno

  • 1Department of Laboratory Medicine, Shinshu University School of Medicine, Matsumoto.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|April 11, 2000
PubMed
Summary

Establishing a genetic laboratory in a Japanese university hospital enabled molecular diagnostic tests and chromosomal analyses for various diseases. This initiative improved diagnostic capabilities and fostered research despite initial costs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Capillary-driven horseshoe vortex forming around a micro-pillar.

Journal of colloid and interface science·2023
Same author

Surgical starting time in the morning versus the afternoon: propensity score matched analysis of operative outcomes following laparoscopic colectomy for colorectal cancer.

Surgical endoscopy·2018
Same author

Administration of platelet concentrates suspended in bicarbonated Ringer's solution in children who had platelet transfusion reactions.

Vox sanguinis·2017
Same author

Donor Left-Sided Heptectomy by Use of the Real-Time Moving Windows Method With 8-Centimeter Transverse Skin Incision.

Transplantation proceedings·2016
Same author

Factors related to allergic transfusion reactions and febrile non-haemolytic transfusion reactions in children.

Vox sanguinis·2016
Same author

A monoclonal antibody-based enzyme-linked immunosorbent assay of aflatoxin B1 in peanut products.

Mycotoxin research·2013

Area of Science:

  • Medical diagnostics
  • Genetics
  • Molecular biology

Background:

  • University hospitals in Japan face challenges establishing genetic laboratories due to high costs and staffing needs.
  • Genetic testing, including molecular diagnostics and chromosomal analyses, is crucial for diagnosing infectious, neoplastic, and genetic diseases.

Purpose of the Study:

  • To describe the establishment and impact of a genetic laboratory at Shinshu University Hospital.
  • To highlight the expansion of molecular diagnostic and chromosomal analysis services.

Main Methods:

  • Implementation of polymerase chain reactions (PCR) for infectious disease diagnosis starting in 1992.
  • Introduction of chromosome analyses in 1996 and spectral karyotyping in 1999.
  • Staffing the laboratory with technologists and faculty members to provide high-quality testing.

Related Experiment Videos

Main Results:

  • The laboratory performed molecular diagnostics for 855 infectious diseases, 25 hematopoietic tumors, and 8 solid tumors in 1998.
  • Chromosome analyses were conducted for 51 hereditary diseases and 29 hematopoietic tumors in 1998.
  • The laboratory grew to include 4 technologists and 3 faculty members by 1999, offering comprehensive services.

Conclusions:

  • Establishing a genetic laboratory in a university hospital, while not cost-saving, positively influences other departments.
  • The laboratory facilitates the application of molecular biology techniques for research and improving routine diagnostic test limitations.