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Prolactin secretion and the immune system.

I C Luca1

  • 1Disciplina de Histologie, Facultatea de Medicină, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.

Revista Medico-Chirurgicala a Societatii De Medici Si Naturalisti Din Iasi
|July 1, 1997
PubMed
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Altered prolactin levels, both high and low, disrupt immune function by affecting lymphocytes. Prolactin receptor presence on lymphocytes highlights its role in immune disorders and autoimmune diseases.

Area of Science:

  • Immunology
  • Endocrinology

Background:

  • Prolactin receptors are present on lymphocytes, which can secrete prolactin.
  • Both decreased and increased plasma prolactin levels are implicated in immune disorders.
  • Prolactin dysfunction is observed in autoimmune conditions like lupus, arthritis, uveitis, experimental allergic encephalomyelitis, and thyroid disease.

Purpose of the Study:

  • To investigate the role of prolactin in immune system regulation.
  • To understand the impact of prolactin level dysregulation on autoimmune diseases.

Main Methods:

  • Identification of prolactin receptors on lymphocyte membranes.
  • Analysis of plasma prolactin levels in relation to immune status.

Main Results:

Related Experiment Videos

  • Lymphocytes possess prolactin receptors and secrete prolactin.
  • Aberrant prolactin levels (both high and low) are linked to immune dysfunction.
  • Prolactin's normal secretion supports lymphocyte function, but abnormal levels can suppress immunity.

    • Conclusions:

    • Prolactin plays a critical dual role in immune regulation, acting as a trophic factor at normal levels and an immunosuppressant at abnormal levels.
    • Dysfunctional prolactin secretion is a significant factor in the pathogenesis of various autoimmune diseases.