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[An immunohistochemical study of the steroid hormone receptors in endometrial hyperplasia]
S Teleman1, M Hilgarth, N Freudenberg
1Disciplina Morfopatologie, Universitatea de Medicină şi Farmacie Gr. T. Popa, Iaşi.
Aim:
Evaluation of the estrogen and progesterone receptors (ER and PR) in different degrees of endometrial hyperplasias.
Methods:
10 cases of each degree of endometrial hyperplasia (simple, complex and atypical) were analyzed using the avidin-biotin-peroxidase technique and monoclonal antibodies applied to formalin-fixed, paraffin-embedded tissue.
Results:
We found similar, high level of both ER and PR in simple and complex hyperplasias and a significant decrease of these in atypical hyperplasia.
Conclusions:
Endometrial hyperplasias develop in a setting of estrogen excess. This explains the high level of endometrial receptors and the response to progesterone in typical hyperplasia. In atypical hyperplasia, the decrease of steroid receptors results in a low sensibility of this lesion to progestative therapy, but there are cases with high receptor levels which could have a chance for hormonal therapy.