Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cancer, aging and cellular senescence.

J Campisi1

  • 1Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA. JCAMPISI@LBL.GOV

In Vivo (Athens, Greece)
|April 11, 2000
PubMed
Summary

Cellular senescence, a process where normal cells stop dividing, acts as a cancer-preventive mechanism. However, the accumulation of senescent cells with age may paradoxically contribute to cancer risk.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Algorithmic assessment of cellular senescence in experimental and clinical specimens.

Nature protocols·2021
Same author

Glass-coated ferromagnetic microwire-induced magnetic hyperthermia for in vitro cancer cell treatment.

Materials science & engineering. C, Materials for biological applications·2019
Same author

Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling.

Oncogene·2015
Same author

Sex and age-related differences in perceived, desired and measured percentage body fat among adults.

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association·2014
Same author

Mitochondrial DNA damage induces apoptosis in senescent cells.

Cell death & disease·2013
Same author

Environmental stress, ageing and glial cell senescence: a novel mechanistic link to Parkinson's disease?

Journal of internal medicine·2013

Area of Science:

  • Cellular Biology
  • Oncology
  • Aging Research

Background:

  • Normal cells cease division via replicative senescence, a process evolved to prevent cancer.
  • Senescent cells exhibit growth arrest, resistance to apoptosis, and altered functions.
  • Short telomeres, DNA damage, and mitogenic signals can induce senescence.

Purpose of the Study:

  • To explore the role of cellular senescence as a protective mechanism against cancer.
  • To investigate why cancer risk increases with age despite senescence.
  • To examine the potential contribution of senescent cells to organismal aging.

Main Methods:

  • Review of evidence linking senescence to cancer protection.
  • Analysis of factors contributing to age-related cancer risk.
  • Discussion of recent findings on senescent cell accumulation in aging tissues.

Main Results:

  • Senescence is a fail-safe mechanism against oncogenic stimuli.
  • Despite senescence, cancer risk increases with age due to mutation accumulation.
  • Senescent cells accumulate with age and may disrupt the tissue microenvironment.

Conclusions:

  • Cellular senescence is a critical anti-cancer mechanism.
  • Age-related accumulation of senescent cells may synergize with mutations to promote cancer.
  • Senescence might play a dual role in aging and cancer development.

Related Experiment Videos