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Microbial transformation of benzosampangine
K Y Orabi1, A M Clark, C D Hufford
1Department of Pharmacognosy and National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, USA.
Abstract:
Microbial transformation studies of the synthetic antifungal alkaloid benzosampangine (1) have revealed that 1 is metabolized by a number of microorganisms. Using a standard two-stage fermentation technique Absidia glauca (ATCC 22752), Cunninghamella blakesleeana (ATCC 8688a), Cunninghamella species (NRRL 5695), Fusarium solani f. sp. cucurbitae (CSIH #C-5), and Rhizopogon species (ATCC 36060) each produced a beta-glucopyranose conjugate of benzosampangine (2). The identity of 2 was established on the basis of spectroscopic data.