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Related Experiment Videos

Glucose absorption in acute peritoneal dialysis.

J Podel1, R Hodelin-Wetzel, D C Saha

  • 1Department of Nutrition, Saint Vincents Hospital and Medical Center, New York, NY, USA.

Journal of Renal Nutrition : the Official Journal of the Council on Renal Nutrition of the National Kidney Foundation
|April 11, 2000
PubMed
Summary

Glucose absorption in acute peritoneal dialysis (APD) differs from continuous ambulatory peritoneal dialysis (CAPD). A 40%-50% estimate is recommended over the CAPD formula due to variations in dwell time and concentration.

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Area of Science:

  • Nephrology
  • Clinical Nutrition
  • Biomedical Engineering

Background:

  • Glucose in peritoneal dialysis (PD) solutions provides significant calories.
  • Glucose absorption is well-documented in continuous ambulatory PD (CAPD) but unclear in acute PD (APD).

Purpose of the Study:

  • To evaluate the appropriateness of using the CAPD formula (Grodstein et al) for calculating glucose absorption in APD patients.
  • To determine actual glucose absorption in APD and compare it with existing formulas.

Main Methods:

  • Measured actual glucose absorption (Method I) in 9 APD patients over 24 hours.
  • Calculated glucose absorption using the Grodstein et al formula (Method II) and compared with Method I.
  • Analyzed the influence of dwell time and dialysate concentration on glucose absorption.

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Main Results:

  • Mean total glucose absorbed was 43% ± 15%.
  • Method I showed cumulative absorption over time, while Method II assumed fixed absorption.
  • Significant differences in glucose absorption were observed between 1.5% and 4.25% dialysate concentrations.

Conclusions:

  • The CAPD formula is inaccurate for APD due to variable dwell times and concentrations.
  • A recommended glucose absorption estimate of 40%-50% for APD is proposed.
  • This estimate accounts for practical limitations in calculating individual exchanges.