Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neonatal neoplasms.

E C Halperin1

  • 1Department of Radiation Oncology, Duke University Medical Center, Durham, NC, USA. halperin@radonc.duke.edu

International Journal of Radiation Oncology, Biology, Physics
|April 12, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prospective study of neuropsychologic testing and quality-of-life assessment of adults with primary malignant brain tumors.

International journal of radiation oncology, biology, physics·2003
Same author

Should academic medical centers conduct clinical trials of the efficacy of intercessory prayer?

Academic medicine : journal of the Association of American Medical Colleges·2001
Same author

The Jewish problem in U.S. medical education, 1920-1955.

Journal of the history of medicine and allied sciences·2001
Same author

Duration of symptoms prior to diagnosis is related inversely to presenting disease stage in children with medulloblastoma.

Cancer·2001
Same author

Non-human to human organ transplantation: its biologic basis and a potential role for radiation therapy.

International journal of cancer·2001
Same author

Second malignant neoplasms of the head and neck in survivors of retinoblastoma.

Ear, nose, & throat journal·2001
Same journal

Single Percussive Ventilation Breath-hold Imaging and Delivery in Lung Tumor Stereotactic Ablative Radiation Therapy: Initial Observations From a Prospective Clinical Trial.

International journal of radiation oncology, biology, physics·2026
Same journal

Proton beam therapy in nonmetastatic rhabdomyosarcoma: Outcome, prognostic factors and the effect of timing of radiation therapy.

International journal of radiation oncology, biology, physics·2026
Same journal

Hypofractionated Proton Reirradiation for Recurrent Glioblastoma: Clinical and Dosimetric Outcomes from a Large Single Institution Series.

International journal of radiation oncology, biology, physics·2026
Same journal

Gastrointestinal Motility-Induced Interplay in Pancreas Proton Therapy: Motion Simulation and Dosimetric Impact.

International journal of radiation oncology, biology, physics·2026
Same journal

Intra-fractional Voxel-wise Anatomical Motion Tracking Guided by Multimodal Respiratory Surrogates in Radiotherapy: Framework Development and Multi-Center Validation.

International journal of radiation oncology, biology, physics·2026
Same journal

A Gaussian-based planning approach for robust dose-escalated stereotactic body proton therapy.

International journal of radiation oncology, biology, physics·2026
See all related articles

This study describes neonatal neoplasms, finding teratoma/germ cell tumors, neuroblastomas, and retinoblastomas most common. These rare childhood cancers can be linked to congenital anomalies, requiring careful treatment considerations.

Area of Science:

  • Pediatric Oncology
  • Neonatal Pathology
  • Cancer Epidemiology

Background:

  • Neonatal neoplasms are rare but present unique diagnostic and therapeutic challenges.
  • Understanding the spectrum of these tumors is crucial for improving outcomes.

Purpose of the Study:

  • To characterize neoplasms diagnosed in neonates (<= 28 days old).
  • To detail their treatments, associated congenital anomalies, and long-term consequences.

Main Methods:

  • Retrospective review of autopsy records, tumor registry, and medical records at Duke University Medical Center (1930-1998).
  • Identification and analysis of 23 neonates with diagnosed neoplasms.

Main Results:

  • Most common diagnoses: teratoma/germ cell tumor (35%), neuroblastoma (22%), and retinoblastoma (17%).

Related Experiment Videos

  • Neoplasms were associated with congenital anomalies (e.g., imperforate anus, limb absence).
  • Long-term survivors were observed, but treatment complications (e.g., anesthesia-related sepsis, radiation effects) occurred.

    • Conclusions:

    • Teratoma/germ cell tumors, neuroblastoma, and retinoblastoma are the most frequent neonatal neoplasms.
    • Congenital anomalies frequently co-occur with neonatal tumors.
    • Radiation therapy, while infrequent, requires careful consideration due to potential long-term effects in this vulnerable population.