Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Macrophage lectins in host defence.

S A Linehan1, L Martínez-Pomares, S Gordon

  • 1Sir William Dunn School of Pathology, South Parks Road, Oxford, UK.

Microbes and Infection
|April 12, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modulation of the immune response to Mycobacterium tuberculosis during malaria/M. tuberculosis co-infection.

Clinical and experimental immunology·2016
Same author

Macrophage receptors and immune recognition.

Annual review of immunology·2005
Same author

Binding properties of the mannose receptor.

Immunobiology·2002
Same author

Endogenous ligands of carbohydrate recognition domains of the mannose receptor in murine macrophages, endothelial cells and secretory cells; potential relevance to inflammation and immunity.

European journal of immunology·2001
Same author

Mannose receptor and scavenger receptor: two macrophage pattern recognition receptors with diverse functions in tissue homeostasis and host defense.

Advances in experimental medicine and biology·2000
Same author

Aldehyde-mannan antigen complexes target the MHC class I antigen-presentation pathway.

European journal of immunology·2000

Macrophage lectins, like mannose receptor (MR) and complement receptor three (CR3), aid host defense against pathogens. Their complex regulation highlights dynamic roles in infection, with CR3 potentially acting as a true pattern recognition receptor.

Area of Science:

  • Immunology
  • Cell Biology
  • Microbiology

Background:

  • Macrophage lectins are crucial for host defense against pathogens.
  • Mannose receptor (MR) and complement receptor three (CR3) are key lectins mediating phagocytosis and microbial killing.
  • The regulatory mechanisms of MR effector functions are complex and involve host and microbial factors.

Purpose of the Study:

  • To elucidate the distinct roles and regulatory mechanisms of macrophage lectins, specifically MR and CR3, in host defense.
  • To investigate the pattern recognition capabilities of MR and CR3 in the context of microbial interactions.
  • To identify the potential involvement of other macrophage lectins in immune responses to microbes.

Main Methods:

  • The study focuses on the functional characterization of macrophage lectins.

Related Experiment Videos

  • Comparative analysis of MR and CR3 in mediating phagocytosis and intracellular killing.
  • Exploration of host and microbial factors influencing MR function.
  • Investigation of CR3 lectin site interactions and ligand binding.

    • Main Results:

    • Both MR and CR3 mediate phagocytosis of pathogenic microbes and induce intracellular killing.
    • MR function is complexly regulated, suggesting dynamic roles beyond classical pattern recognition.
    • CR3's lectin site appears to lack host-derived ligands, indicating a potential role as a true pattern recognition receptor.
    • The precise roles of other macrophage lectins in microbial recognition and response remain under-characterized.

    Conclusions:

    • Macrophage lectins MR and CR3 are vital for host defense, with distinct functional and regulatory properties.
    • MR exhibits complex regulatory pathways, while CR3 may function as a direct pattern recognition receptor.
    • Further research is necessary to fully understand the contribution of various macrophage lectins to host-microbe interactions.