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Related Experiment Videos

Cyclic ADP-ribose.

A H Guse1

  • 1University of Hamburg, Institute for Medical Biochemistry and Molecular Biology, Division of Cellular Signal Transduction, Germany. guse@uke.uni-hamburg.de

Journal of Molecular Medicine (Berlin, Germany)
|April 12, 2000
PubMed
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Cyclic ADP-ribose mobilizes calcium ions (Ca2+) and is vital for cell signaling across many species. Antagonists of cyclic ADP-ribose have confirmed its role in fertilization and immune cell activation.

Area of Science:

  • Biochemistry
  • Cell Biology
  • Physiology

Background:

  • Cyclic ADP-ribose (cADPR) is a natural Ca2+-mobilizing compound.
  • Its role in Ca2+ signaling is established in diverse organisms, from protozoa to humans.
  • ADP-ribosyl cyclases, including CD38, synthesize cADPR.

Purpose of the Study:

  • To summarize the established roles of cyclic ADP-ribose in Ca2+ signaling.
  • To highlight the enzymes involved in cADPR synthesis.
  • To present the use of cADPR antagonists in functional studies.

Main Methods:

  • Review of existing literature on cyclic ADP-ribose.
  • Identification of candidate enzymes (e.g., CD38) responsible for cADPR synthesis.
  • Synthesis and application of cADPR antagonists.

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Main Results:

  • Cyclic ADP-ribose mobilizes intracellular Ca2+ via the ryanodine receptor.
  • cADPR plays key roles in fertilization, insulin secretion, and T-lymphocyte activation.
  • Antagonistic derivatives of cADPR have been successfully synthesized and utilized.

Conclusions:

  • Cyclic ADP-ribose is a crucial signaling molecule involved in various physiological processes.
  • Understanding cADPR pathways offers potential therapeutic targets.
  • Further research into cADPR and its modulators is warranted.