Related Experiment Videos
Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein
S Matsuda1, K Miyazaki, Y Ichigotani
1Department of Molecular Pathogenesis, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Japan. smatsuda@tsuru.med.nagoya-u.ac.jp
Biochimica Et Biophysica Acta
|April 13, 2000
Abstract:
A full-length cDNA encoding a novel protein was isolated and sequenced from a human placental cDNA library. This cDNA consists of 1990 bp and has a predicted open reading frame encoding 433 amino acids. It possesses an Src homology 3 (SH3) motif, a leucine zipper motif and no catalytic domain, suggesting that it seems to be an adapter protein. PCR-based mapping with both a monochromosomal hybrid panel and radiation hybrid cell panels placed the gene to human chromosome 1q21-22.