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Related Experiment Videos

[Tamm-Horsfall protein].

M Pressac1

  • 1Laboratoire de biochimie, Hôpital Armand-Trousseau, 26, avenue du Dr-Arnold-Netter, 75012 Paris, France.

Annales De Biologie Clinique
|April 13, 2000
PubMed
Summary

Human Tamm-Horsfall glycoprotein (THP), a major urinary protein, is a membrane-bound protein with unclear functions. Research suggests THP may play roles in kidney water impermeability and protecting against bacterial infections like E. coli.

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Area of Science:

  • Nephrology
  • Glycobiology
  • Urology

Context:

  • Tamm-Horsfall glycoprotein (THP) is the primary protein found in human urine.
  • It is a glycosyl-phosphatidyl-inositol (GPI)-anchored membrane protein located on cells in the kidney's thick ascending limb (TAL) and early distal tubules.
  • THP contains N-linked glycans, including polyantennary and high-mannose types, with significant sialylation and fucosylation.

Purpose:

  • To elucidate the physiological functions of human Tamm-Horsfall glycoprotein.
  • To investigate the potential roles of THP in renal physiology and pathology.
  • To explore the implications of THP in kidney disease and host defense.

Summary:

  • Tamm-Horsfall glycoprotein (THP) is a major urinary protein anchored to the membrane of kidney tubule cells.
  • While its exact function is unknown, THP's gel-forming properties suggest a role in TAL water impermeability.
  • THP may also protect against pathogens like Escherichia coli by preventing colonization of the renal mucosa.

Impact:

  • Understanding THP's function could reveal new insights into kidney water balance and TAL physiology.
  • THP's proposed role in pathogen defense may have implications for preventing urinary tract infections and pyelonephritis.
  • Recent findings link urinary THP to tubulointerstitial nephritis, highlighting its clinical relevance in kidney disease.

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