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Bone wound healing after maxillary molar extraction in ovariectomized aged rats: quantitative backscattered electron
M Shimizu1, R Furuya, T Kawawa
1First Department of Prosthodontics, School of Dentistry, Showa University, 2-1-1 Kitasenzoku, Ohta-ku, Tokyo 145-8515, Japan.
The Anatomical Record
|April 13, 2000
Summary
Ovariectomized (OVX) rats showed impaired bone wound healing after maxillary molar extraction. New bone formation was significantly reduced in OVX rats compared to controls, indicating osteoporosis negatively impacts healing processes.
Area of Science:
- Oral and Maxillofacial Surgery
- Bone Biology
- Osteoporosis Research
Background:
- Maxillary molar extraction triggers bone wound healing processes.
- Ovariectomy (OVX) in aged rats is a model for postmenopausal osteoporosis.
- Estrogen deficiency impacts bone metabolism and healing.
Purpose of the Study:
- To investigate the effect of OVX-induced osteoporosis on bone wound healing after maxillary molar extraction.
- To quantitatively assess new bone formation in the maxilla of OVX rats.
Main Methods:
- Quantitative backscattered electron image analysis and energy-dispersive X-ray microanalysis were employed.
- Maxillary first molars were extracted from sham-operated and OVX aged rats.
- Bone healing was assessed at 7, 30, and 60 days post-extraction.
Main Results:
- New bone formation occurred in both sham-operated and OVX rats, increasing over time.
- OVX rats exhibited significantly reduced new bone formation on the buccal bone surface and within alveolar sockets compared to controls.
- These findings demonstrate impaired bone regeneration in the context of OVX-induced osteoporosis.
Conclusions:
- OVX-induced osteoporosis significantly impairs bone wound healing following maxillary molar extraction.
- Reduced bone formation in OVX rats highlights the detrimental role of estrogen deficiency in skeletal repair.
- The study provides quantitative evidence of compromised healing in an osteoporosis model.