Related Experiment Video
Updated: Aug 13, 2026

Optimization of the Ugi Reaction Using Parallel Synthesis and Automated Liquid Handling
Published on: November 11, 2008
Simulation of organic reactions: from the degradation of chemicals to combinatorial synthesis
Hollering1, Gasteiger, Steinhauer
1Computer-Chemie-Centrum, Institut fur Organische Chemie, Universitat Erlangen-Nurnberg, Germany. Gasteiger@CCC.Chemie.Uni-Erlangen.DE
Abstract:
Organic reactions can be run under a variety of conditions, from laboratory experiments, through technical processes, to combinatorial chemistry. The scope is further extended when the metabolism of compounds and the reactions in the mass spectrometer are included. We present here several concepts: reactors, phases, and modes, which, together with a kinetic modeling, allow the treatment of such a broad scope of organic reactions. These concepts have been implemented in a knowledge-based system, EROS. Several applications of this system to the wide world of organic reactions are given.
Related Concept Videos
Synthesis and Decomposition Reactions
SN2 Reaction: Kinetics
In a chemical reaction, a relationship exists between the concentration of reactants and the rate at which the reaction proceeds. The study to measure this relationship is known as the kinetics of a chemical reaction. Kinetic studies are used to deduce the rate law of a chemical reaction, which provides information about the species involved during the transition state of the rate-determining step. Thus, kinetic studies help to derive the mechanism of a reaction.
E1 Reaction: Kinetics and Mechanism
Cycloaddition Reactions: Overview
Radical Chain-Growth Polymerization: Overview
Radical Chain-Growth Polymerization: Mechanism

![Solid-phase Synthesis of [4.4] Spirocyclic Oximes](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58508.jpg&w=3840&q=50)