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Diabetic mastopathy. A clinicopathologic review
1Division of Anatomic Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
American Journal of Clinical Pathology
|April 13, 2000
Summary
Diabetic mastopathy, a rare breast condition, can occur in individuals with and without diabetes. This study highlights its varied presentation and potential for recurrence, emphasizing the need for accurate diagnosis to avoid unnecessary biopsies.
Area of Science:
- Endocrinology
- Pathology
- Oncology
Background:
- Diabetic mastopathy is an uncommon lymphocytic mastitis with stromal fibrosis.
- It is typically associated with long-standing type 1 diabetes mellitus.
Purpose of the Study:
- To correlate clinical history and disease recurrence in diabetic mastopathy.
- To evaluate the histopathologic criteria for diabetic mastopathy and its specificity.
Main Methods:
- Retrospective analysis of 19 cases meeting histopathologic criteria for diabetic mastopathy.
- Correlation of clinical data, including patient history and disease recurrence.
- Histopathologic examination of breast tissue.
Main Results:
- Palpable masses or nodularity were common, predominantly subareolar.
- Histopathology revealed lymphocytic ductitis/lobulitis with fibrosis, vasculitis, and lymphoid nodules.
- Diabetic mastopathy occurred in patients with type 1 diabetes, type 2 diabetes, and those without diabetes.
- Six of 19 cases recurred, with varied patterns (ipsilateral, contralateral, bilateral).
Conclusions:
- The histopathologic features of diabetic mastopathy are confirmed.
- The specificity of these features is questioned due to similar findings in non-diabetic patients and those with type 2 diabetes.
- Diabetic mastopathy can present as solitary or bilateral disease and may recur, necessitating careful diagnosis to prevent repeat biopsies.