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Influenza and respiratory syncytial virus. Update on infection, management, and prevention
1Division of Pediatric Infectious Disease, North Shore University Hospital-New York University School of Medicine, Manhasset, USA.
Insights
This article reviews influenza and respiratory syncytial virus in children, detailing their diseases, pathogenesis, and host responses. It highlights the need for vaccines and discusses current and future preventive strategies.
Area of Science:
- Pediatric infectious diseases
- Virology
- Immunology
Background:
- Influenza and respiratory syncytial virus (RSV) are significant causes of childhood respiratory illness.
- Understanding their epidemiology and clinical spectrum is crucial for public health.
Purpose of the Study:
- To provide an overview of influenza and RSV in children.
- To discuss the pathogenesis and host responses for each virus.
- To highlight the importance of vaccine development and review current/future preventive measures.
Main Methods:
- Literature review and synthesis of existing data on influenza and RSV in pediatric populations.
- Comparative analysis of disease mechanisms and host immune responses.
- Review of current vaccination strategies and emerging vaccine technologies.
Main Results:
- Detailed description of the epidemiology and clinical manifestations of influenza and RSV in children.
- Elucidation of distinct viral pathogenesis and host immune pathways for each infection.
- Summary of existing preventive measures and promising future vaccine candidates.
Conclusions:
- Influenza and RSV pose substantial disease burdens in children, necessitating targeted interventions.
- Understanding pathogenesis and host response underscores the critical need for effective vaccines.
- Advancements in vaccine technology offer hope for improved prevention of these common childhood infections.
Abstract:
This article is an overview of the epidemiology and spectrum of clinical disease attributed to influenza and respiratory syncytial virus in children. It separately discusses the pathogenesis of the two diseases and the host responses to the viruses to emphasize each infection's significance and need for a vaccine. Updates on current preventive measures and a preview of potential future vaccine developments are presented.