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Obesity and diabetes.

K S Leong1, J P Wilding

  • 1University Clinical Department, University Hospital Aintree, Liverpool, UK.

Bailliere'S Best Practice & Research. Clinical Endocrinology & Metabolism
|April 13, 2000
PubMed
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Obesity, especially abdominal obesity, increases diabetes and cardiovascular risks. Effective obesity treatment requires a comprehensive approach combining diet, exercise, behavioral changes, and potentially medication for sustained weight loss and improved health.

Area of Science:

  • Metabolic Syndrome and Endocrinology
  • Obesity Research
  • Pharmacology

Background:

  • Truncal obesity is strongly linked to increased prevalence of diabetes and cardiovascular disease.
  • Elevated plasma leptin, tumor necrosis factor-alpha, and non-esterified fatty acids in obesity contribute to insulin resistance.
  • While obesity reduction improves glycemic control and insulin resistance, sustained weight loss is challenging with diet alone.

Purpose of the Study:

  • To review the relationship between obesity and associated metabolic diseases.
  • To discuss the challenges and strategies for effective obesity management.
  • To evaluate the role of pharmacological interventions in conjunction with lifestyle modifications for weight reduction and metabolic improvement.

Main Methods:

Related Experiment Videos

  • Literature review of studies on obesity, metabolic diseases, and weight management strategies.
  • Analysis of the mechanisms by which obesity-related factors impact insulin resistance.
  • Evaluation of the efficacy and tolerability of current and emerging anti-obesity medications.

    • Main Results:

    • Obesity reduction leads to improvements in diabetic glycemic control and insulin resistance.
    • Dietary management alone is rarely sufficient for sustained weight reduction.
    • Newer anti-obesity drugs like orlistat and sibutramine show promise in improving glycemic control in diabetic patients when used as part of a comprehensive plan.

    Conclusions:

    • Effective obesity treatment necessitates a multimodal strategy including hypocaloric diets, education, low-impact exercise, and behavioral techniques.
    • Weight-reducing drugs are valuable adjuncts to comprehensive obesity management plans.
    • Future pharmacological treatments may target various pathways regulating body weight, potentially requiring combination therapy for optimal outcomes.