Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Diabetic hypoglycaemia.

S R Heller1

  • 1Clinical Sciences Centre, Northern General Hospital, Sheffield, UK.

Bailliere'S Best Practice & Research. Clinical Endocrinology & Metabolism
|April 13, 2000
PubMed
Summary
This summary is machine-generated.

Hypoglycaemia, or low blood sugar, hinders diabetes management in insulin-treated patients. Addressing defective responses and unawareness through education is crucial until better insulin therapies emerge.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cardiac arrhythmias and electrophysiologic responses during spontaneous hyperglycaemia in adults with type 1 diabetes mellitus.

Diabetes & metabolism·2021
Same author

Sustained type 1 diabetes self-management: Specifying the behaviours involved and their influences.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

What are the characteristics of the best type 1 diabetes patient education programmes (from diagnosis to long-term care), do they improve outcomes and what is required to make them more effective?

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

Reducing the burden of hypoglycaemia in people with diabetes through increased understanding: design of the Hypoglycaemia REdefining SOLutions for better liVEs (Hypo-RESOLVE) project.

Diabetic medicine : a journal of the British Diabetic Association·2020
Same author

How has psycho-behavioural research advanced our understanding of hypoglycaemia in type 1 diabetes?

Diabetic medicine : a journal of the British Diabetic Association·2019
Same author

Hypoglycaemia is reduced with use of inhaled Technosphere<sup>®</sup> Insulin relative to insulin aspart in type 1 diabetes mellitus.

Diabetic medicine : a journal of the British Diabetic Association·2019
Same journal

Inhibin B in the assessment of seminiferous tubular function.

Bailliere's best practice & research. Clinical endocrinology & metabolism·2001
Same journal

Post-Chernobyl thyroid carcinoma in children.

Bailliere's best practice & research. Clinical endocrinology & metabolism·2001
Same journal

Surgical approach to thyroid nodules and cancer.

Bailliere's best practice & research. Clinical endocrinology & metabolism·2001
Same journal

Diagnosis and treatment of medullary thyroid cancer.

Bailliere's best practice & research. Clinical endocrinology & metabolism·2001
Same journal

Management of undifferentiated thyroid cancer.

Bailliere's best practice & research. Clinical endocrinology & metabolism·2001
Same journal

Papillary and follicular thyroid carcinoma.

Bailliere's best practice & research. Clinical endocrinology & metabolism·2001
See all related articles

Area of Science:

  • Endocrinology
  • Metabolic Disorders
  • Diabetes Management

Background:

  • Hypoglycaemia (low blood glucose) is a significant barrier to achieving normoglycaemia in patients treated with insulin.
  • Current insulin therapies often lead to supra-physiological post-absorptive insulin levels, contributing to hypoglycaemia.
  • Physiological counter-regulatory responses, including autonomic activation, normally protect against falling glucose levels and provide warning symptoms.

Purpose of the Study:

  • To examine the impact of hypoglycaemia on insulin-treated patients.
  • To understand the mechanisms behind defective hypoglycaemia responses and unawareness.
  • To explore potential interventions for managing hypoglycaemia and its consequences.

Main Methods:

  • Review of physiological defence mechanisms against hypoglycaemia.

Related Experiment Videos

  • Analysis of factors contributing to defective autonomic responses and hypoglycaemia unawareness.
  • Discussion of the implications of recurrent hypoglycaemia on cognitive function and mortality.
  • Consideration of future technological advancements in glucose monitoring and insulin delivery.

    • Main Results:

    • Patients on insulin often experience hypoglycaemia due to treatment limitations.
    • Longstanding diabetes or intensive glycaemic control can impair the body's response to low blood sugar.
    • Repeated hypoglycaemic episodes can lead to impaired cerebral glucose uptake and loss of warning symptoms.
    • Preventing further hypoglycaemia can partially restore defective responses and symptomatic awareness.

    Conclusions:

    • Hypoglycaemia remains a critical challenge in insulin therapy, impacting patient safety and quality of life.
    • Defective counter-regulation and unawareness of hypoglycaemia can result from disease duration and treatment intensity.
    • Clinical hypoglycaemia is linked to adverse outcomes like 'dead in bed' syndrome and cognitive impairment.
    • While technological solutions are forthcoming, enhanced patient education is vital for mitigating hypoglycaemia risks.