Synthesis of a novel class of cdc25A inhibitors from vitamin D3
K Dodo1, M Takahashi, Y Yamada
1Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan.
Bioorganic & Medicinal Chemistry Letters
|April 13, 2000
Abstract:
We have developed a novel class of cdc25A inhibitors by drastic modification of the hydrophobic and hydrophilic substructures of dysidiolide. The unsaturated derivative 3b strongly inhibited cdc25A (IC50 = 7.7 microM) and caused GI arrest of HL60 cells.
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