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Synthesis of 19-[(2-azido-5-iodo)-benzoyloxy]-LTA4 and enzymatic conversion to the LTC4 analogue
1Laboratoire de Chimie Biomoléculaire et Interactions Biologiques associé au C.N.R.S., Université Montpellier 1, Faculté de Pharmacie, France.
Bioorganic & Medicinal Chemistry Letters
|April 13, 2000
Abstract:
New photoaffinity probes based on C-19 position of leukotriene A4 has been synthesized from 19-hydroxy-LTA4 methyl ester. Enzymatic conversion into the LTC4 analogue yielded a potential tool for the study of cys-LT2 receptors.